NAC

Paracetamol (also known as acetaminophen) is one of the most commonly used medications around the world for treating pain and fever. However, an overdose of paracetamol can lead to severe liver damage and even death. Paracetamol is a readily available over-the-counter medication, which means it is easy for patients to obtain and take an overdose, whether intentionally or unintentionally. Paracetamol poisoning is one of the most common causes of acute liver failure in many Western countries. While therapeutic doses of paracetamol are safe for the liver, overdoses can lead to centrilobular hepatic necrosis. The liver damage occurs due to a toxic metabolite called N-acetyl-p-benzoquinone imine (NAPQI), which causes oxidative stress and glutathione depletion.